Low expression of lncRNA-HMlincRNA717 in human gastric cancer and its clinical significances

• DOI: 10.1007/s13277-014-2243-z
• Publication Date: 2014-06-24T11:50:31Z
• Authors: Yongfu Shao; Huilin Chen; Xiaoming Jiang; Shengcan Chen; Peifei Li; Meng Ye; Qier Li; Weiliang Sun; Junming Guo
• Keywords: Male; Reverse Transcriptase Polymerase Chain Reaction; Adenocarcinoma; Middle Aged; Real-Time Polymerase Chain Reaction; Immunohistochemistry; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Stomach Neoplasms; Cell Line, Tumor; Biomarkers, Tumor; Humans; Female; RNA, Long Noncoding; Aged

Long noncoding RNAs (lncRNAs) have been gradually confirmed to be tumor-associated biological molecules in recent years. However, the clinical significances of most lncRNAs screening gastric cancer are largely unknown. Based on our lncRNA array results, this study, we explored potential relationship between HMlincRNA717 expression levels and clinicopathologic factors cancer. A total 313 samples were collected from two centers, then level human tissues cell lines was measured by real-time reverse transcription-polymerase chain reaction. Then, at multiple stages tumorigenesis investigated association it levels, clinicopathological features analyzed. The five lines, AGS, BGC-823, HGC-27, MGC-803, SGC-7901, significantly downregulated than those normal mucosal epithelial line GES-1. It not only 62.6 % (67/107) compared with paired adjacent but also precancerous lesions. More importantly, results indicated that correlated distal metastasis (P = 0.034), venous invasion 0.029), nervous 0.024). Our data suggested lncRNA-HMlincRNA717 may play crucial roles during occurrence progression a new biomarker early