Effects of interleukin-18 promoter (C607A and G137C) gene polymorphisms and their association with oral squamous cell carcinoma (OSCC) in northern India

• DOI: 10.1007/s13277-014-2538-0
• Publication Date: 2014-11-14T17:21:56Z
• Authors: Prithvi Kumar Singh; Mohd. Kaleem Ahmad; Vijay Kumar; Syed Rizwan Hussain; Rajni Gupta; Amita Jain; Abbas Ali Mahdi; Jaishri Bogra; Girish Chandra
• Keywords: Gene polymorphism

Interleukin-18 (IL-18) is one of the immunomodulatory cytokines that plays an important role in cellular functions against tumor development and progression. IL-18 (-607) C/A (-0137) G/C gene promoter polymorphisms their haplotypes variants are associated with risk various cancers. We evaluated a possible association (-137) susceptibility to oral squamous cell carcinoma (OSCC). A total number 272 patients OSCC 185 healthy volunteers were genotyped for polymorphism. Polymorphism examined by using tetra-primer amplification refractory mutation system (T-ARMS). Genotype frequencies chi-square test odds ratio (OR) relative risk. polymorphism was significantly as compared (genotype GG vs GC: OR 2.238; 95 % CI 1.455-3.441; p = 0.0003 allele G C: 1.984; 1.335–2.947; 0.0007). The genotype -607 not different than controls (p > 0.05). Our results suggest -137 progression cancer but this.