Evidence of cell fusion in carcinogen-induced mice gastric carcinoma

• DOI: 10.1007/s13277-015-3160-5
• Publication Date: 2015-02-05T05:12:31Z
• Authors: Yongjia Yan; Yiling Hsu; Xianghui He; Ning Lu; Wei Wei; Zhixiang Zhang; Liwei Zhu
• Keywords: Cell fusion

The role of bone marrow-derived cells in gastric cancer formation was not fully understood. In this study, marrow from female green fluorescent protein transgenic mice transplanted into male wild-type to generate sex-mismatched chimeric mice. were treated with carcinogen induce cancer. At time sacrifice, 18.2 % (2/11) showed severe dysplasia and 25 (3/12) successfully induced Fluorescence situ hybridization results that participated renewal mucosa cell fusion observed both precancerous lesions adenocarcinoma, but no sign squamous carcinoma. Our findings suggest participate during chronic damage might have acquired the phenotype epithelial through fusion. Fusion between involved increased carcinogenesis.