Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer

• DOI: 10.1007/s13277-015-3416-0
• Publication Date: 2015-04-09T05:47:36Z
• Authors: Juan Wang; Hongtao Chen; Yifeng Liao; Nan Chen; Tianze Liu; Huitao Zhang; Hongyu Zhang
• Keywords: Tensin; Clinical Significance

The aim of this study was to explore the expression and clinical significance miR-494 PTEN (phosphatase tensin homologue deleted on chromosome ten) in non-small cell lung cancer (NSCLC). Immunohistochemistry for situ hybridization (ISH) were performed 92 NSCLC tissues 10 normal detect their expression, correlation between with characteristics prognosis analyzed. significantly higher than (P = 0.004). positive protein carcinoma lower that 0.013), while level negatively correlated (r -0.577, P < 0.01). high rate positively pathological TNM (p-TNM) staging lymph node metastasis. grade differentiation. However, Patients over-expression had a shorter overall survival (OS), negative group poor OS. MiR-494 low are closely related tumor p-TNM metastasis, differentiation, Combined detection can aid determining malignancy degree patients NSCLC. may be served as novel prognostic factor lead new treatment strategies