Exon 19 deletion of epidermal growth factor receptor is associated with prolonged survival in brain metastases from non-small-cell lung cancer

• DOI: 10.1007/s13277-015-3653-2
• Publication Date: 2015-06-19T22:44:08Z
• Authors: Hongwei Li; Xiaqin Zhang; Jianzhong Cao; Pengcheng Su; Jianhong Lian; Xing Song; Weihua Yang; Songyan Han; Yanfeng Xi; Yaohua Wang
• Keywords: Log-rank test

Brain metastasis (BM) is a poor prognostic factor for non-small-cell lung cancer (NSCLC). Recent studies have shown that oral epidermal growth receptor (EGFR) tyrosine kinase inhibitors (TKIs) were effective BM from NSCLC with EGFR mutation. However, the relationship between mutations and prognosis of patients remains to be determined. In this study, we investigated impact mutation status on survival NSCLC. One hundred six retrospectively reviewed. Thirty-three subjects (24.3 %) confirmed an exon 19 deletion, while another 33 had 21 point (L858R) %). Log-rank test Cox proportional hazards model used analyze variables survival. The median was 8 months. analysis showed Eastern Cooperative Oncology Group Performance Status (ECOG-PS) at (p < 0.0001), control primary tumor = 0.005), pathology 0.01), 0.045), deletion 0.007) associated longer model, 0.034), 0.024), ECOG PS 0.006) found independent factors. Moreover, there differences groups according Radiation Therapy (RTOG) recursive partitioning (RPA) classification system 0.0001). Exon in It should integrated into scoring