The role of RhoA in vulvar squamous cell carcinoma: a carcinogenesis, progression, and target therapy marker

• DOI: 10.1007/s13277-015-4087-6
• Publication Date: 2015-09-26T07:14:22Z
• Authors: Jing Wang; Qiong Wu; Li-hua Zhang; Yun-xia Zhao; Xin Wu
• Keywords: MMP2

Ras homologue gene family member A (RhoA) is involved in tumor mobility, invasion, and metastasis. We detected RhoA expression vulvar squamous cell carcinoma (VSCC) tissue, measured the VSCC phenotype, of relevant molecules after small interfering RNA (siRNA) transfection SW962 cells. has a higher level than normal vulva skin tissue was positively associated with International Federation Gynecology Obstetrics (FIGO) stage differentiation; besides, patients lymph node metastasis had positive expression. messenger protein significantly reduced siRNA transfectants as compared negative control (NC) mock-transfected cells (p < 0.05). The lead to low growth, G1 arrest, high apoptosis, migration invasion 0.05), suppressed lamellipodia formation NC Besides, matrix metalloproteinase-2 (MMP2), MMP9, cyclinA1 downregulated, while that Bax upregulated proliferation rates were lovastatin dose-dependent. Lovastatin caused suppression formation. Similar transfectants, treatment downregulated RhoA, MMP2, expression, upregulating Abnormal may be target. inhibitor alters effective for treating VSCC.