Active cigarette smoking and the risk of breast cancer at the level of N-acetyltransferase 2 (NAT2) gene polymorphisms

• DOI: 10.1007/s13277-015-4685-3
• Publication Date: 2015-12-23T12:44:00Z
• Authors: Petra Kasajova; Veronika Holubekova; Andrea Mendelova; Zora Lasabova; Pavol Zubor; Erik Kudela; Kristina Biskupsk...; Jan Danko
• Keywords: Adult; Aged, 80 and over; Nicotiana; Polymorphism, Genetic; Arylamine N-Acetyltransferase; Smoking; Breast Neoplasms; Middle Aged; Prognosis; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Case-Control Studies; Humans; Female; Aged

The aim of our study was to assess the correlation between tobacco exposure and NAT2 gene (rs1041983 C/T, rs1801280 T/C, rs1799930 G/A) polymorphisms in association with breast cancer development. We wanted determine prognostic clinical importance these smoking cancer. For detection possible smoking, polymorphisms, risk cancer, we designed a case-controlled 198 patients enrolled, 98 100 healthy controls. Ten milliliters peripheral blood from cubital vein withdrawn every patient. HRM (high resolution melting) analysis used for three abovementioned polymorphisms. When comparing group women more than 5 cigarettes day fewer day, found out that if were carriers aberrant AA genotype rs1799930, first had higher carcinoma second group. If TT rs1041983, rs1801280CC genotype, rs1799930AA they smoked malignant disease never-smoking women. Our results confirm hypothesis long-period active could be individual risk-predicting factors development population Slovak