Expression and significance of Hippo/YAP signaling in glioma progression

• DOI: 10.1007/s13277-016-5318-1
• Publication Date: 2016-10-06T22:55:15Z
• Authors: Hao Zhang; Decheng Geng; Jian Gao; Yanhua Qi; Yi Shi; Yan Wang; Yang Jiang; Yu Zhang; Jiale Fu; Yu Dong; Shangfeng Gao; Rutong Yu; Xiuping Zhou
• Keywords: Hippo signaling pathway; YAP1

Dysregulation of Hippo/YAP signaling leads to aberrant cell growth and neoplasia. Although the roles regulation were extensively studied in cancer biology recently, study systematically checking expression pattern core components this pathway at tumor tissue level remains lacking. In study, we thoroughly examined profile patient specimens both mRNA protein levels. We found that YAP1/TAZ their target genes, CRY61, CTGF, BIRC5, was remarkably amplified glioma tissues. Consistently, increased meanwhile those p-YAP1/p-TAZ LATS1/2 decreased gliomas. Unexpectedly, levels MST1/2 tissues, inconsistent with its presumed suppressor identity. addition, over-expression LATS2 decreased, while YPA1 proliferation ability. Furthermore, based on data from free public database, BIRC5 positively associated prognosis patients, exhibited negative correlation prognosis. Collectively, deduce that, context, may not be essential component hippo/YAP pathway. Moreover, our findings uncover a new evidence supporting YAP1/TAZ-BIRC5 might abnormally activated due down-regulation, which turn promote occurrence development gliomas, paving way identify potential therapeutic molecular for