Boundary Cap Neural Crest Stem Cells Promote Survival of Mutant SOD1 Motor Neurons

• DOI: 10.1007/s13311-016-0505-8
• Publication Date: 2017-01-09T16:45:46Z
• Authors: Tanya Aggarwal; Jan Hoeber; Patrik Ivert; Svitlana Vasylovska; Elena N Kozlova
• Keywords: Cell Survival; Clinical Neurology; Mice, Nude; Mice; 03 medical and health sciences; Superoxide Dismutase-1; Neural Stem Cells; Animals; Humans; Pharmacology (medical); Neurodegeneration; Cells, Cultured; Pharmacology; Motor Neurons; Transplantation; 0303 health sciences; Amyotrophic Lateral Sclerosis; Neurosciences; Amyotrophic lateral sclerosis; 3. Good health; Oxidative stress; Neural Crest; Mutation; Original Article; Neuroglia; Neurovetenskaper; Stem Cell Transplantation

ALS is a devastating disease resulting in degeneration of motor neurons (MNs) the brain and spinal cord. The survival MNs strongly depends on surrounding glial cells neurotrophic support from muscles. We previously demonstrated that boundary cap neural crest stem (bNCSCs) can give rise to vitro vivo have multiple beneficial effects co-cultured co-implanted cells, including cells. In this paper, we investigate if bNCSCs may improve harboring mutant form human SOD1 (SOD1