New insights into HLA class I association to Behçet’s syndrome in Iranian Azari patients

• DOI: 10.1007/s13317-013-0047-6
• Publication Date: 2013-02-11T02:38:01Z
• Authors: Fatemeh Zare Shahneh; Fatemeh Hamzavi; Babak Bayazi; Ali Bandehagh; Behzad Baradaran
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Short Communication; 3. Good health

Behçet's syndrome (BS) is a chronic recurrent inflammatory disorder characterized by oral and genital ulcers and ocular inflammation. BS has a complex genetic etiology. To evaluate the influence of human leukocyte antigen (HLA) class I in BS susceptibility in Iranian Azari population, we studied 290 BS patients and 300 healthy controls. As expected, a high frequency of HLA-B5 was found. Remarkably, HLA-B35 frequency was higher in the patient than control group, and the frequency of HLA-B51, HLA-B52, and HLA-BW4 was significantly elevated. Thus, HLA-B5 and HLA-B35 seem to confer susceptibility to BD in Iranian Azari patients.