Controlled release of pharmaceutical agents using eutectic modified gelatin

• DOI: 10.1007/s13346-021-00998-3
• Publication Date: 2021-05-08T20:02:37Z
• Authors: Wanwan Qu; Idrees B. Qader; Andrew P. Abbott
• Keywords: Catechol

Deep eutectic solvent (DES) is a class of ionic liquids, consisting mixture generally formed by combining hydrogen bond donors (HBDs) such as alcohols, amides and carboxylic acids with various quaternary ammonium salts. The decrease in melting points the constituents due to charge delocalization during formation bonding between acceptor donor. This can be considered one main reasons for increasing solubility absorption DESs. Most active pharmaceutical ingredients (APIs) have polar functional groups containing amide, acid, alcohol or groups. These tend increase point compounds, but they used form mixtures. While this concept has previously used, combination salts amides, alcohols result large depressions freezing so-called deep solvents are formed. DESs mix readily water so could uptake APIs. In study, (PDESs) formulated from 3 APIs: imipramine HCl, ascorbic acid catechol. PDESs were plasticise gelatine. It shown that materials rate API via both oral transdermal delivery modes. Thus, concentration solution reaches maximum before pure drugs. Particularly catechol, after 1 s, dissolution was more than twice drug. Moreover, mode PDES based on HCl patch 15 min found 65% compared just which released only 20%.