3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release

• DOI: 10.1007/s13346-023-01506-5
• Publication Date: 2024-01-07T18:01:21Z
• Authors: Elena Munoz-Perez; J. Rubio-Retama; Lorena Cussó; Manoli Igartua; Rosa Maria Hernandez; Edorta Santos-Viz...
• Keywords: Biofabrication; Suppository

Traditional approaches to solid rectal therapies have halted progress, leading a continual decline in the use of conventional suppositories. Additive manufacturing techniques been recently explored as suitable innovative tool for suppository fabrication. However, little advancement has made composition materials 3D-printed (3DPS) and still, vehicles are often used construct fabrication, hindering growth field. As novelty, this study unveils ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, proposes novel approach loading drugs into 3DPS employing first time post-printing loading. Thus, passive strategy molecular models is developed, demonstrating versatility capacity load molecules different charges sizes within matrix systems. This allows adapting wide range single ink, which simplifies speeds up technological development process with physico-chemical properties. Additionally, research, displacement three-dimensional Laponite matrices developed order enhance drug release through their disintegration capacity, resulting significant improvement diffusion hydrogel rapid Finally, our demonstrates that obtained vivo behavior, being non-obstructive allowing normal motility rats intestine.