Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient

• DOI: 10.1007/s13365-025-01255-w
• Publication Date: 2025-04-21T16:39:42Z
• Authors: Ryosuke Koyamada; Mariko Nishihara; Tetsuhiro Masaki; Tomohito Shimada; Kazuhiro Ishikawa; Jun Hashimoto; Nobuyoshi Mori; Asami Namai; Hideaki Yokoo; Kenta Takahashi; Tadaki Suzuki; Kazuo Nakamichi; Shinichiro Mori
• Keywords: Bendamustine; Palbociclib; Follicular lymphoma

Abstract A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab bendamustine had finished 6.5 years ago. Discontinuing palbociclib using mirtazapine, she is alive year after diagnosis PML. It rare for to be diagnosed long the last dose rituximab bendamustine. We will discuss possible involvement in course