Progesterone suppresses the invasion and migration of breast cancer cells irrespective of their progesterone receptor status - a short report

• DOI: 10.1007/s13402-017-0330-z
• Publication Date: 2017-06-26T08:28:15Z
• Authors: Mukul Godbole; Kanishka Tiwary; Rajendra Badwe; Sudeep Gupta; Amit Dutt
• Keywords: Progesterone receptor

Pre-operative progesterone treatment of breast cancer has been shown to confer survival benefits patients independent their receptor (PR) status. The underlying mechanism and the question whether such an effect can also be observed in PR negative cells remain resolved.We performed proteome profiling PR-positive PR-negative response using a phospho-kinase array platform. Western blotting was used validate results. Cell-based phenotypic assays were conducted assess progesterone.We found that induces de-phosphorylation 12 out 43 kinases tested, which are mostly involved cellular invasion migration regulation. Consistent with this observation, we through cell-based inhibits status.Our results indicate inhibit cell mediated by kinases. This inhibition appears status cells. In broader context, our study may provide basis for association between recurrence reduction patients, thereby providing lead modelling randomized vitro study.