Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers

• DOI: 10.1007/s13402-021-00601-4
• Publication Date: 2021-04-17T09:02:58Z
• Authors: Niclas C. Blessin; Wenchao Li; Tim Mandelkow; Hannah L. Jansen; Cheng Yang; Jonas B. Raedler; Ronald Simon; Franziska Büscheck; David Dum; Andreas M. Luebke; Andrea Hinsch; Katharina Möller; Anne Menz; Christian Bernreu...; Patrick Lebok; Till Clauditz; Guido Sauter; Andreas Marx; Ria Uhlig; Waldemar Wilczak; Sarah Minner; Till Krech; Christoph Fraune; Doris Höflmayer; Eike Burandt; Stefan Steurer
• Keywords: Tissue microarray

Expansion of CD8+ cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era checkpoint therapy.To understand T cell dynamics tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate proliferation (Ki67 co-expression) tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic 347 gastric cancer samples.The density percentage proliferating (Ki67+) cells were both highly variable between types as well patients with same type. Elevated significantly associated favorable parameters such low stage, negative nodal stage (p ≤ 0.0041 each), prolonged overall survival 0.0028 each) an inflamed phenotype = 0.0025) colorectal and, contrast, linked high advanced ISUP/Fuhrman/Thoenes grading (each p 0.003), shorter 0.0330 0.0094) cancer. In role (Ki67+)CD8+ Tcells was not clinicopathological data.Our data demonstrate type dependent prognostic impact inverse