Outcomes of Biologic Use in Asian Compared with Non-Hispanic White Adult Psoriasis Patients from the CorEvitas Psoriasis Registry

• DOI: 10.1007/s13555-022-00843-6
• Publication Date: 2022-11-16T17:04:57Z
• Authors: Chen Yu; Gang Wang; Russel T. Burge; Erjia Ye; Guanshen Dou; Jinnan Li; Ryan W. Harrison; Robert R. McLean; Samantha J. Kerti; Jerry Bagel
• Keywords: Body surface area

Real-world data are limited comparing Asian and White patients with psoriasis using biologic therapy. This study compared the 6-month effectiveness of therapy between plaque in CorEvitas Psoriasis Registry. Analyses included initiations follow-up visits from self-identified (n = 293) 2314) USA/Canada (4/2015–4/2020). Outcomes included: Area Severity Index (PASI) 75, disease activity measures [body surface area (BSA) ≤ 1, BSA 3, PASI90, PASI100, Investigator's Global Assessment (IGA) 0/1], patient-reported outcomes [Dermatology Life Quality (DLQI) 0/1, itch, fatigue, skin pain, EuroQoL visual analog scale (EQ-VAS), patient global assessment, Work Productivity Activity Impairment (WPAI) domains]. Unadjusted regression models were used to calculate odds ratios (OR) 95% confidence intervals (CI) for achievement binary difference mean change continuous (β, CI) at 6 months, followed by adjustment age, sex, body mass index, alcohol, smoking, health insurance, education, comorbidities, scalp morphology, psoriatic arthritis, class, previous biologics, baseline outcome value. Asians had lower proportions women (32.8% versus 49.1%) obesity (27.3% 54.5%), higher on Medicaid (19.9% 8.8%), graduated college (50.9% 40.1%) never smoked (67.1% 44.1%). In unadjusted analyses, 52% achieving PASI75 (OR 1.52; CI 1.15, 2.02). After adjustment, association was attenuated 1.11; 0.81, 1.52). Secondary experienced similar patterns except DLQI: 33% DLQI 0/1 both 0.67; 0.50, 0.90) adjusted 0.49, 0.92) models. differences likely explained demographic, lifestyle, characteristics groups. However, still lesser improvements skin-related quality life, even after adjustment.