Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

• DOI: 10.1007/s13659-012-0018-z
• Publication Date: 2012-03-19T22:48:04Z
• Authors: Yan Li; Chang-Wei Li; Cheng-Bin Cui; Xing-Zhong Liu; Yong-Sheng Che
• Keywords: Regular Article; 01 natural sciences; 0104 chemical sciences

Three new caryophyllene sesquiterpenoids, cytosporinols A-C (1–3), have been isolated from solid cultures of Cytospora sp. The structures of 1–3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed by X-ray crystallography. The absolute configurations of the C-11 secondary alcohol in 1 and the 6,8-diol moiety in 3 were deduced using the modified Mosher and Snatzke’s method, respectively. Compounds 2 and 3 showed moderate cytotoxicity against HeLa cells. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0018-z and is accessible for authorized users.