Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

• DOI: 10.1007/s13659-025-00512-z
• Publication Date: 2025-04-24T08:29:00Z
• Authors: Hongyan Wen; Sheng Li; Yu Zhang
• Keywords: Phthalide; Angelica sinensis

Abstract Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A ( 1 ) and B 2 ), a monomer 3 were obtained from the rhizomes Angelica sinensis . Their structures established through spectroscopic methods, quantum calculations, chiral HPLC analysis. Compounds [2 + 2] [4 cycloadducts monomers, their hypothetical biogenetic origin was proposed. , (+)- (−)- 4 exhibited significant inhibitory activity against NO production with IC 50 values range 1.23 to 5.55 μM. Graphical