Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile

• DOI: 10.1007/s13770-024-00679-5
• Publication Date: 2024-11-04T07:05:10Z
• Authors: Jonas Campos; Belém Sampaio-Mar...; Diogo Santos; Sandra Barata-Ant...; Miguel Ribeiro; Sofia C. Serra; Tiffany S. Pinho; João Canto-Gomes; Ana Marote; Margarida Cortez; Nuno A. Silva; Adina T. Michael-...; António J. Salgado
• Keywords: Priming (agriculture); Senescence

Priming strategies that improve the functionality of MSCs may be required to address issues limiting successful clinical translation MSC therapies. For conditions requiring high trophic support such as brain and spinal cord injuries, priming produce higher levels factors instrumental facilitate current We developed tested a novel molecular paradigm using docosahexaenoic acid (DHA) prime adipose tissue-derived mesenchymal stromal cells (ASCs) enhance secretome neuroregulatory potential.