COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry

• DOI: 10.1007/s15010-021-01587-9
• Publication Date: 2021-03-01T11:04:49Z
• Authors: Jesús Porta-Etessam; Iván J. Núñez-Gil; Nuria González Ga...; Cristina Fernande...; María C. Viana-Ll...; Charbel Maroun Eid; Rodolfo Romero; María Molina; Aitor Uribarri; Victor Manuel Bec...; Marcos García Aguado; Jia Huang; Elisa Rondano; Enrico Cerrato; Emilio Alfonso; Alex Fernando Cas...; Francisco Marin; Sergio Raposeiras...; Martino Pepe; Gisela Feltes; Paloma Maté; Bernardo Cortese; Luis Buzón; Jorge Játiva Mendez; Vicente Estrada
• Keywords: Anosmia; Dyslipidemia; Hyposmia

Olfactory and gustatory dysfunctions (OGD) are a frequent symptom of coronavirus disease 2019 (COVID-19). It has been proposed that the neuroinvasive potential novel SARS-CoV-2 could be due to olfactory bulb invasion, conversely studies suggest it good prognostic factor. The aim current study was investigate prognosis value OGD in COVID-19. These symptoms were recorded on admission from cohort 5868 patients with confirmed or highly suspected COVID-19 infection included multicenter international HOPE Registry (NCT04334291). There statistical relation multivariate analysis for gender, more female 12.41% vs 8.67% male, related age, under 65 years, presence hypertension, dyslipidemia, diabetes, smoke, renal insufficiency, lung, heart, cancer neurological disease. We did not find differences pregnant (p = 0.505), patient suffering cognitive 0.484), liver 0.1) immune 0.32). inverse (protective) between prone positioning (0.005) death (< 0.0001), but no ICU (0.165) mechanical ventilation (0.292). On univariable logistic regression, found inversely patients. odds ratio 0.26 (0.15–0.44) < 0.001) Z − 5.05. anosmia is fundamental diagnosis SARS.CoV-2 infection, also important classifying therapeutic decisions. Even knowing an early Knowing other situations as being Afro-American Latino-American, increase C-reactive protein (CRP) imply worse we can make clinical score estimate vital patient. exact pathogenesis causes gustative disorders remains unknown seems prognosis. This point fundamental, insomuch plausible way treatment.