Evaluation of the clinical relevance of the Biofire© FilmArray pneumonia panel among hospitalized patients

• DOI: 10.1007/s15010-023-02080-1
• Publication Date: 2023-08-12T06:01:47Z
• Authors: Kirstine K. Søgaard; Vladimira Hinic; Daniel Goldenberger; Alexander Gensch; Michael Schweitzer; Veronika Bättig; Martin Siegemund; Stefano Bassetti; Roland Bingisser; Michael Tamm; Manuel Battegay; Maja Weisser; Daiana Stolz; Nina Khanna; Adrian Egli
• Keywords: Univariate analysis; Microbiological culture

Abstract Purpose Panel PCR tests provide rapid pathogen identification. However, their diagnostic performance is unclear. We assessed the of Biofire © FilmArray pneumonia (PN)-panel against standard culture in broncho-alveolar lavage (BAL) samples. Methods Setting: University Hospital Basel (February 2019 to July 2020), including hospitalized patients with a BAL (± pneumonia). determined sensitivity and specificity PN-panel culture. Using univariate logistic regression, we calculated odds ratios (OR) for according status, stratifying by chronic pulmonary disease. ORs different pathogens estimate clinical relevance. Results included 840 adult patients, 60% were males, median age was 68 years, 35% had disease, 21% pneumonia, 36% recent antibiotic use. In 1078 samples, bacterial detected 16% culture, respectively. The overall high, whereas positive predictive value low. OR 1.1 (95% CI 0.7–1.6) PN-panel-positive only; 2.6 1.3–5.3) culture-positive only, 1.6 1.0–2.4) culture-positive. detection rate Haemophilus influenzae , Staphylococcus aureus, Moraxella catarrhalis high but not associated pneumonia. Conclusion While are compared did correlate well diagnosis. Patients highest pneumonia—thus impact on management needs further evaluation randomized controlled trials.