Validity and Reliability of the 32-Item Motor Function Measure in 2- to 5-Year-Olds with Neuromuscular Disorders and 2- to 25-Year-Olds with Spinal Muscular Atrophy

• DOI: 10.1007/s40120-020-00206-3
• Publication Date: 2020-08-27T19:03:51Z
• Authors: Dylan Trundell; Stephanie Le Scou...; Ksenija Gorni; Timothy Seabrook; Carole Vuillerot
• Keywords: Convergent validity

To investigate the validity and reliability of 32-item Motor Function Measure (MFM32) in individuals with neuromuscular disorders (NMD), including spinal muscular atrophy (SMA), aged 2–5 years, non-ambulant Types 2 or 3 SMA, 2–25 years. Test–retest (intraclass correlation coefficient [ICC]), internal consistency (Cronbach's alpha [α]), convergent (Spearman rank-order correlations), known-groups (analysis covariance comparing groups defined by Clinical Global Impression Severity [CGI-S] scale Vignos grade) were calculated. The analysis was performed on a dataset provided Hospices Civils De Lyon, extracted from multinational MFM32 database. A total 165 included analyses, whom 84 NMD group (aged years) 81 SMA years). Strong evidence test–retest (ICC: 2- to 5-years' population = 0.94–0.95; 25-years' 0.97), α: 0.96; 0.95), (2- population: CGI-S rho − 0.84, grade 0.79; 0.49), (all P < 0.001) demonstrated. These analyses provide supportive younger NMDs, supporting use across wide age range.