Ischemic Stroke and Cerebral Microbleeds: A Two-Sample Bidirectional Mendelian Randomization Study

• DOI: 10.1007/s40120-023-00500-w
• Publication Date: 2023-06-03T16:01:35Z
• Authors: Renjie Liu; Xin Shi; Jiahui Feng; Jianmin Piao; Zhongxi Yang; Yuhao Zhao; Haoyuan Yin; Xuan Chen
• Keywords: Mendelian Randomization; Bonferroni correction; Stroke; Genetic Association; Genome-wide Association Study

Recent observational studies have reported the association between ischemic stroke (IS) and cerebral microbleeds (CMBs). Whether this reflects a causal remains to be established. Herein, we adopted two-sample bidirectional Mendelian randomization (MR) analysis comprehensively evaluate of IS CMBs.The summary-level genome-wide (GWASs) data were obtained from GIGASTROKE consortium (62,100 European ancestry cases 1,234,808 controls). All could further divided into large-vessel atherosclerosis (LVS, n = 6399), cardio-embolic (CES, 10,804) small-vessel occlusion (SVS, 6811). Meanwhile, used publicly available summary statistics published GWASs CMBs (3556 25,862 participants across 2 large initiatives). A MR was conducted using inverse-variance weighting (IVW) as major outcome, whereas MR-Egger weighted median (WM) complement IVW estimates they can provide more robust in broader set scenarios but are less efficient (wider CIs). Bonferroni-corrected threshold p < 0.0125 considered significant, values 0.05 suggestive evidence for potential association.We detected that higher risk [IVW odds ratio (OR) 1.47, 95% confidence interval (CI) 1.04-2.07, 0.03] SVS (IVW OR 1.62, CI 1.07-2.47, 0.02) significantly associated with CMBs. Reverse analyses found no significant effect on its subtypes.Our study provides causally linked increased Further research is needed determine mechanisms