Axial Shortening in Myopic Children after Repeated Low-Level Red-Light Therapy: Post Hoc Analysis of a Randomized Trial

• DOI: 10.1007/s40123-023-00671-7
• Publication Date: 2023-02-17T07:29:31Z
• Authors: Wei Wang; Yu Jiang; Zhuoting Zhu; Shiran Zhang; Meng Xuan; Xingping Tan; Xiangbin Kong; Hui Zhong; Gabriella Bulloch; Ruilin Xiong; Yixiong Yuan; Yanping Chen; Jian Zhang; Junwen Zeng; Ian G. Morgan; Mingguang He
• Keywords: Post-hoc analysis

Axial length (AL) elongation in myopia is considered irreversible. We aimed to systemically report unexpected AL shortening observed a randomized clinical trial (RCT) after repeated low-level red-light (RLRL) therapy. This post hoc analysis of multicenter, single-masked RCT. Two hundred sixty-four myopic children aged 8–13 years allocated RLRL treatment (intervention group) or single vision spectacle (SVS, control were included. was measured using an IOL-master 500 at baseline, 1-, 3-, 6-, and 12-month follow-up visits. defined as reduction from baseline visits three cutoffs: > 0.05 mm, 0.10 0.20 mm. Frequency different cutoffs calculated. Analysis done with intent treat (ITT). At 12-months follow up, frequency mm 26/119 (21.85%) 2/145 (1.38%) for the group versus group, respectively. The 18/119 (15.13%) 0/145 (0%) 7/119 (5.88%) (0%), respectively (p < 0.001). Mean 12 months (SD) −0.156 (0.086) −0.06 group. Age significantly associated multivariable analysis. For that exhibited (n = 56), choroidal thickness (ChT) thickening (0.056 mm) could only explain 28.3% (−0.20 mm). Nearly quarter had following therapy, whereas rarely occurred among controls. ClinicalTrials.gov (NCT04073238).