N-Acetylcysteine Effects on Transforming Growth Factor-β and Tumor Necrosis Factor-α Serum Levels as Pro-Fibrotic and Inflammatory Biomarkers in Patients Following ST-Segment Elevation Myocardial Infarction

• DOI: 10.1007/s40268-013-0025-5
• Publication Date: 2013-09-18T12:03:08Z
• Authors: Azita Hajhossein ...; Hossein Khalili; Yaser Jenab; Mojtaba Salarifar; Mohammad Ali Brou...; Farzad Darabi
• Keywords: GDF15

Ischemia following acute myocardial infarction (AMI) increases the level of pro-fibrotic and inflammatory cytokines, including transforming growth factor (TGF)-β tumor necrosis (TNF)-α. N-acetylcysteine (NAC) has therapeutic benefits in management patients with AMI. To best our knowledge, this is first study that evaluated effect NAC on TNF-α TGF-β levels Following confirmation AMI, 88 were randomly administered 600 mg (Fluimucil®, Zambon, Ticino, Switzerland) or placebo orally twice daily for 3 days. For quantification serum after 24 72 h administration, peripheral venous blood (10 mL) samples collected at these time points. Comparisons between within groups revealed there was not any significant difference except group, which increased significantly over (p = 0.042). Significant relationships existed patients' ejection fraction 0.005) levels. Receiving could prevent from increasing as compared receiving NAC. As had strong correlations fraction, its antagonism seems to be important prevention remodeling.