Routine Surveillance of Chemotherapy Toxicities in Cancer Patients Using the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)

• DOI: 10.1007/s40487-018-0065-7
• Publication Date: 2018-10-22T15:18:29Z
• Authors: Tian Qi Wang; Joseph N. Samuel; M. Catherine Brown; Ashlee Vennettilli; Hannah Solomon; Lawson Eng; Mindy Liang; Gursharan Gill; Zahra Merali; Chenchen Tian; Nicholas Y. H. Cheng; Matthew Campbell; Devalben Patel; Ai Xin Liu; Geoffrey Liu; Doris Howell
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Chemotoxicity; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; PRO-CTCAE; Side-effects monitoring; Patient reported outcome; RC254-282; Cancer; Original Research; 3. Good health

Systematic documentation of chemotoxicities in outpatient clinics is challenging. Incorporating patient-reported outcome (PRO) measures clinical workflows can be an efficient strategy to strengthen the assessment symptomatic treatment toxicities oncology practice. We compared adequateness, feasibility, and acceptability toxicity using systematic, prospective, application PRO Common Toxicity Criteria for Adverse Events (PRO-CTCAE) tool. At a comprehensive cancer center, data abstraction electronic health record reviews elucidated current methods degree chemotoxicity documentation. Web-based 32-item PRO-CTCAE questionnaires, administered ambulatory patients receiving chemotherapy, captured respective severities. Patient telephone surveys assessed whether healthcare providers had addressed patients' satisfaction. Over broad demographic 497 90% (95% CI 84–96%) with significant (n = 107) reported that their discussed them; these, 70% received therapy management change, while among rest, 17% desired change management. Of surveyed, 91% 82–99%) were satisfied Clinician chart varied greatly; descriptors rather than numerical grading scales typically used. Although 93% willing complete survey, only 50% thought it would acceptable this survey at routine clinic visits. Use practice promotes systematic evaluation improves clarity, consistency, efficiency clinician documentation; however, improve patient willingness tool routinely are needed.