Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release

• DOI: 10.1007/s40544-020-0437-5
• Publication Date: 2021-01-11T06:05:40Z
• Authors: Kuan Zhang; Jielai Yang; Yulong Sun; Yi Wang; Jing Liang; Jing Luo; Wenguo Cui; Lianfu Deng; Xiangyang Xu; Bo Wang; Hongyu Zhang
• Keywords: Gelatin; Phosphorylcholine; Diclofenac Sodium

Abstract The occurrence of osteoarthritis is closely related to progressive and irreversible destruction the articular cartilage, which increases friction significantly causes further inflammation joint. Thus, a scaffold for cartilage defects should be developed via lubrication restoration drug intervention. In this study, we successfully synthesized gelatin-based composite hydrogels, namely GelMA-PAM-PMPC, with properties biomimetic sustained release by photopolymerization methacrylic anhydride modified gelatin (GelMA), acrylamide (AM), 2-methacryloyloxyethyl phosphorylcholine (MPC). Tribological test showed that hydrogels remarkably enhanced due hydration mechanism, where tenacious shell was formed around zwitterionic phosphocholine headgroups. addition, indicated efficiently encapsulated an anti-inflammatory (diclofenac sodium) achieved release. Furthermore, in vitro revealed were biocompatible, mRNA expression both anabolic catabolic genes suitably regulated. This could effectively protect chondrocytes from inflammatory cytokine-induced degeneration. summary, provide local represent promising treatment osteoarthritis.