Evaluation of fluid status in patients with acromegaly through bioelectrical impedance vector analysis: a cross-sectional study

• DOI: 10.1007/s40618-025-02541-4
• Publication Date: 2025-02-15T08:31:53Z
• Authors: Emanuele Varaldo; Nunzia Prencipe; Alessandro Maria ...; Daniela Cuboni; Luigi Simone Aversa; Michela Sibilla; Francesca Mocellini; Fabio Bioletto; Ezio Ghigo; Valentina Gasco; Silvia Grottoli
• Keywords: Bioelectrical Impedance Analysis; Cross-sectional study

The acromegalic state is associated with an increase in total body water and sodium. aim of our study was to assess the hydration status patients acromegaly using bioimpedance vector analysis (BIVA), differentiating according their disease (active, medically controlled or cured) compare confidence tolerance ellipses BIVA those relation a reference healthy population. We analyzed data from 73 consecutive aged 18 years older, diagnosed undergoing regular follow-up at Division for whom available. Patients were evaluated through insulin-like growth factor I (IGF-I), hormone (GH), serum sodium potassium, creatinine, glucose, HbA1c plasma urine osmolality collected. Exclusion criteria concurrent presence arginine-vasopressin deficiency, dysnatremia pathologies known significantly alter extracellular fluid. Sixty-nine (M/F 34/35, age 60 ± 14 years) enrolled study. As expected, active (n = 22) presented higher IGF-I GH levels compared other subjects. 33) older than individuals (p 0.028 vs. disease, p 0.024 cured disease). Compared population, either showed significant fluid overload < 0.0001 both males females) demonstrated that there no differences between two groups 0.363). On hand, 14) reduced 0.016), although difference observed 0.308). results demonstrate present overhydration population alterations content usually improve disease.