Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

• DOI: 10.1007/s40820-020-00585-0
• Publication Date: 2021-02-27T13:02:45Z
• Authors: Jiahui He; Zixi Zhang; Yutong Yang; Fenggang Ren; Jipeng Li; Shaojun Zhu; Feng Ma; Rongqian Wu; Yi Lv; Gang He; Baolin Guo; Dake Chu
• Keywords: Technology; Adhesive hydrogel; T; Gastric hemostasis; Gastric wound healing; Endoscopic treatment; 02 engineering and technology; 0210 nano-technology; Injectable self-healing hydrogel; Article; 3. Good health

Abstract Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are well-established therapeutics for gastrointestinal neoplasias, but complications after EMR/ESD, including bleeding perforation, result in additional treatment morbidity even threaten the lives of patients. Thus, designing biomaterials to treat gastric wound healing is highly desired remains a challenge. Herein, series injectable pH-responsive self-healing adhesive hydrogels based on acryloyl-6-aminocaproic acid (AA) AA-g-N-hydroxysuccinimide (AA-NHS) were developed, their great potential as sprayable bioadhesive materials efficiently stop hemorrhage promote process was further demonstrated swine hemorrhage/wound model. The showed suitable gelation time, an autonomous efficient capacity, hemostatic properties, good biocompatibility. With introduction AA-NHS micro-cross-linker, exhibited enhanced strength. A vivo model that performance by stopping acute arterial preventing delayed bleeding. indicated excellent effects with significantly type I collagen deposition, α-SMA expression, blood vessel formation. These wounds treatment.