Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model

• DOI: 10.1007/s40820-021-00666-8
• Publication Date: 2021-06-19T10:02:21Z
• Authors: Hai-Yi Feng; Yihang Yuan; Yunpeng Zhang; Hai-Jun Liu; Xiao Dong; Si-Cong Yang; Xue-Liang Liu; Xing Lai; Mao-Hua Zhu; Jue Wang; Qin Lu; Quanjun Lin; Hong-Zhuan Chen; Jonathan F. Lovell; Peng Sun; Chao Fang
• Keywords: Primary tumor

Tumor lymph node (LN) metastasis seriously affects the treatment prognosis. Studies have shown that nanoparticles with size of sub-50 nm can directly penetrate into LN metastases after intravenous administration. Here, we speculate through introducing targeting capacity, nanoparticle accumulation in would be further enhanced for improved local such as photothermal therapy. Trastuzumab-targeted micelles (< 50 nm) were formulated using a unique surfactant-stripping approach yielded concentrated phthalocyanines strong near-infrared absorption. Targeted micellar phthalocyanine (T-MP) was an effective transducer and ablated HT-29 cells vitro. A HER2-expressing colorectal cancer cell line (HT-29) used to establish orthotopic mouse model developed metastatic disease mesenteric sentinel LN. T-MP accumulated more compared conjugated control IgG. Following surgical resection primary tumor, minimally invasive T-MP, but not micelles, extended survival. Our findings demonstrate first time targeted small-sized potential enable superior paradigms dealing metastases.