Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring

• DOI: 10.1007/s40820-023-01225-z
• Publication Date: 2023-11-29T14:02:31Z
• Authors: Yuewei Chen; Yanyan Zhou; Zihe Hu; Weiying Lu; Zhuang Li; Ning Gao; Nian Liu; Yuanrong Li; Jing He; Qing Gao; Zhijian Xie; Jiachun Li; Yong He
• Keywords: Gelatin; Bioelectronics; Biocompatibility; Micromechanics

Implantable hydrogel-based bioelectronics (IHB) can precisely monitor human health and diagnose diseases. However, achieving biodegradability, biocompatibility, high conformality with soft tissues poses significant challenges for IHB. Gelatin is the most suitable candidate IHB since it a collagen hydrolysate substantial part of extracellular matrix found naturally in tissues. This study used 3D printing ultrafine fiber networks metamaterial design to embed into ultra-low elastic modulus hydrogel create novel gelatin-based conductive film (GCF) mechanical programmability. The regulation GCF nearly covers tissue mechanics, an from 20 420 kPa, Poisson's ratio - 0.25 0.52. negative promotes improve efficiency biological interfaces. heartbeat signals respiratory rate by determining cardiac deformation due its conformability. Notably, gelatin characteristics biodegradable enable sensor support restoration. offers unique idea develop implantable sensors that integrate monitoring repair customized method endowing implanted be highly conformal