Pushing the boundaries of C–H bond functionalization chemistry using flow technology

• DOI: 10.1007/s41981-020-00077-7
• Publication Date: 2020-02-14T13:03:03Z
• Authors: Sebastian Govaerts; Alexander Nyuchev; Timothy Noel
• Keywords: Surface Modification; Flow chemistry; Microreactor; Reactivity

Abstract C–H functionalization chemistry is one of the most vibrant research areas within synthetic organic chemistry. While researchers focus on development small-scale batch-type transformations, more recently such transformations have been carried out in flow reactors to explore new chemical space, boost reactivity or enable scalability this important reaction class. Herein, an up-to-date overview bond reactions continuous-flow microreactors presented. A comprehensive which establish formal conversion a into carbon–carbon carbon–heteroatom bonds provided; includes metal-assisted cleavages, hydrogen atom transfer and functionalizations involve S E -type process aromatic olefinic systems. Particular devoted showcase advantages processing enhance Consequently, it our hope that review will serve as guide inspire push boundaries using technology.