Two-dimensional superlattice films of gold nanoparticle-polystyrene composites: a bioactive platform for bone homeostasis maintenance

• DOI: 10.1007/s42114-023-00738-w
• Publication Date: 2023-09-16T06:02:23Z
• Authors: Zaikai Zhuang; Zheng Li; Guangyu Gong; Qiangqiang Li; Yibo Zhang; Caoxing Huang; Yusen Huang; Lei Tian; Peng Wang; Zhirui Guo; Qing Jiang
• Keywords: 02 engineering and technology; 0210 nano-technology

Abstract Osseo-integration between the implant and bone is a crucial factor to create strong, durable bond that allows function effectively. However, regular surface with poor osseo-integration ability may cause aseptic loosening, resulting in failure of implants. Herein, serial macroscopic one-particle thick superlattice films generated by self-assembly diverse size gold nanoparticles (GNPs) were termed as SFGs considered bioactive coatings for enhancing osseo-integration. A hydroquinone-assisted seed method established fabricate homogenous GNPs controllable sizes (20, 60, 90 nm), which further employed building blocks generate (SFGs-20, SFGs-60, SFGs-90) assistance ploystryrene. The present size-dependent performance on homeostasis, where SFGs-90 demonstrated most pronounced facilitation osteogenic differentiation osteoblasts well deactivation osteoclasts compared SFGs-20 SFGs-60. Considering universal applicability depositing various substrates, these enhanced capabilities could serve platform modification orthopedic implants, effectively addressing issue loosening. Graphical abstract Two-dimensional nanoparticle-polystyrene composites exhibit osteogenic-stimulation osteoclastic-inhibition effects regulating homeostasis maintenance.