Biological Studies on Anthra[1,9-cd]pyrazol-6(2D)-one Analogues as Anti-vascular Endothelial Growth Factor Via In silico Mechanisms

• DOI: 10.1007/s42250-021-00276-2
• Publication Date: 2021-09-09T12:03:33Z
• Authors: Abel Kolawole Oye...; Olatomide A. Fadare; Sunday Adewale Ak...; Banjo Semire
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Breast cancer still remains one of the dangerous ailments among women globally. The havoc caused by this disease has drawn the attention of many researchers which are intensely seeking for a lasting solution to this malignant neoplasia. Thus, anti-VEGF activities of twenty-six anthra[1,9-cd]pyrazol-6(2d)-one derivatives were investigated via in silico method. The obtained descriptors proved the that studied compounds have a drug-like properties. The studied and the proposed compounds proved to be effective against VEGF than the referenced drug. Also, 7-(benzylamino)dibenzo[cd,g]indazol-6(2H)-one (12) with − 6.8 kcal/mol and proposed compound D (2-amino-7-fluorodibenzo[cd,g]indazol-6(2H)-one) (− 6.4 kcal/mol) have better ability to inhibit VEGF than other studied compounds. ADMET properties of the selected compounds were observed and reported.