Real-World Data on the Use of Hypertonic Saline Nasal Spray in ENT Practice

• DOI: 10.1007/s42399-019-0050-y
• Publication Date: 2019-02-09T15:02:11Z
• Authors: Christoph Bergmann; Karolina Müller; Uta Thieme; Florian Zeman; Gunnar Huppertz; Michael Koller; Peter Meiser
• Keywords: Hypertonic saline; Nasal spray

Hypertonic saline solutions are in broad medicinal use for treatment of various disorders nose and paranasal sinuses. This trial aimed at the evaluation safety efficacy a hypertonic nasal spray within scope routine care an otorhinolaryngological outpatient setting. One hundred thirty-six patients were included into this uncontrolled clinical received 2.7% solution spray. Symptoms signs documented on ordinal scale 0–4 during initial final examination, both individual symptoms sum symptom scores (clinical score) assessed. Participating physicians furthermore evaluated benefit therapy. Clinical score decreased from 13.63 ± 6.65 to 7.85 6.79 (p < 0.001) between significant improvements observed 10 out 12 symptoms. A was attributed by more than 50% cases. Seventy percent noticed improvement breathing, considered alternative α-sympathomimetics. adverse event (epistaxis) reported, whereas 95% rated as flawless. Eleven pregnant women one nursing mother participated without occurrence any negative effect child. study substantiates safe efficacious Reduction classical decongestants constitutes valuable therapeutic option whom these drugs is contraindicated. Trial Register: DRKS-ID: DRKS00010825