Change in National Dosing Advice of Nitroprusside After Potentially Fatal Cyanide Intoxication

• DOI: 10.1007/s42399-020-00261-9
• Publication Date: 2020-04-28T21:02:33Z
• Authors: Guido Bothof; Koen P. van Rhee; Erik Koomen; Esther S. Veldhoen
• Keywords: Sodium nitroprusside; Formulary; Cyanide Poisoning

Abstract The aim of this brief communication is to provide a short overview cyanide intoxication following infusion sodium nitroprusside (SNP). SNP fast-acting antihypertensive drug frequently used in hypertensive emergencies. Although widely known as safe use drug, it can cause potentially lethal intoxication. difficulty diagnose and pharmacological principles will be discussed. Hereby, we like regain attention for severe complication. As result our experience, the Dutch national paediatric formulary has been updated with additional warnings recommendations. Cyanide due difficult recognize complication outcome. Clinicians prescribing should always aware its toxic effects.