Age-Adjusted Risk Factors Associated with Mortality and Mechanical Ventilation Utilization Amongst COVID-19 Hospitalizations—a Systematic Review and Meta-Analysis

• DOI: 10.1007/s42399-020-00476-w
• Publication Date: 2020-08-29T12:02:38Z
• Authors: Urvish Patel; Preeti Malik; Muhammad Shariq U...; Deep Mehta; Ashish Sharma; Faizan Ahmad Malik; Nashmia Khan; Tariq Jamal Siddiqi; Jawad Ahmed; Achint Patel; Henry Sacks
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Covid-19; 3. Good health

The increasing COVID-19 cases in the USA have led to overburdening of healthcare regard invasive mechanical ventilation (IMV) utilization as well mortality. We aim identify risk factors associated with poor outcomes (IMV and mortality) hospitalized patients. A meta-analysis observational studies epidemiological characteristics PubMed, Web Science, Scopus, medRxiv from December 1, 2019 May 31, 2020 following MOOSE guidelines was conducted. Twenty-nine full-text detailing characteristics, symptoms, comorbidities, complications, were included. Meta-regression performed evaluate effects complications on using a random-effects model. pooled correlation coefficient (r), 95% CI, OR calculated. Of 29 (12,258 confirmed cases), 17 reported IMV 21 deaths. prevalence 23.3% (95% CI: 17.1-30.9%), mortality 13% (9.3-18%). age-adjusted meta-regression models showed significant association male (r: 0.14; OR: 1.15; 1.07-1.23; I2: 95.2%), comorbidities including pre-existing cerebrovascular disease 0.35; 1.42 (1.14-1.77); 96.1%), chronic liver 0.08; 1.08 (1.01-1.17); 96.23%), like septic shock 0.099; 1.10 (1.02-1.2); 78.12%) ARDS 0.04; 1.04 (1.02-1.06); 90.3%), ICU admissions 0.03; 1.03 (1.03-1.05); 95.21%), 0.05; 1.05 (1.03-1.07); 89.80%). Similarly, (1.02-1.15); 95%), 0.29; 1.34 (1.09-1.63); I2:93.4%), cardiovascular 0.28; 1.32 (1.1-1.58); 89.7%) had higher odds utilization. patients disease, outcomes. Diabetes hypertension but no IMV. Our study results will be helpful right allocation resources towards who need them most.