Efficient production of mannosylerythritol lipids by a marine yeast Moesziomyces aphidis XM01 and their application as self-assembly nanomicelles

• DOI: 10.1007/s42995-022-00135-0
• Publication Date: 2022-06-27T11:02:41Z
• Authors: Guanshuo Yu; Xiaoxiang Wang; Chao Zhang; Zhe Chi; Zhenming Chi; Guanglei Liu
• Keywords: 0303 health sciences; 03 medical and health sciences; Research Paper

Mannosylerythritol lipids (MELs) are one of the most promising biosurfactants because their excellent physicochemical properties, high environmental compatibility, and various biological functions. In this study, a mangrove yeast strain Moesziomyces aphidis XM01 was identified used for efficient extracellular MEL production. The titer reached 64.5 ± 0.7 g/L at flask level within 7 days with optimized nitrogen carbon source 2.0 NaNO3 70 soybean oil. Furthermore, during 10-L two-stage fed-batch fermentation, final 113.6 3.1 8 days, prominent productivity yield 14.2 g·L-1·day-1 94.6 g/g(glucose oil). Structural analysis indicated that produced MELs were mainly MEL-A its fatty acid profile composed only medium-chain acids (C8-C12), especially C10 (77.81%). Further applications compound evaluated as one-step self-assembly nanomicelles. obtained nanomicelles showed good stability antibacterial activity. addition, using clarithromycin model hydrophobic drug, exhibited loading capacity could be controlled sustained drug release in low-pH environments. Therefore, M. is an candidate production, prepared have broad application prospects pharmaceutical cosmetic fields.The online version contains supplementary material available 10.1007/s42995-022-00135-0.