Natural Cycle Results in Lower Implantation Failure than Ovarian Stimulation in Advanced-Age Poor Responders Undergoing IVF: Fertility Outcomes from 585 Patients

• DOI: 10.1007/s43032-020-00455-5
• Publication Date: 2021-01-22T20:03:27Z
• Authors: Maria Paola De Marco; Giulia Montanari; Ilary Ruscito; Annalise Giallonardo; Filippo Maria Ubaldi; Laura Rienzi; Flavia Costanzi; Donatella Caserta; Mauro Schimberni; Matteo Schimberni
• Keywords: Implantation failure; Natural cycle; Ovarian Reserve

Abstract To compare pregnancy rate and implantation in poor responder women, aged over 40 years, who underwent natural cycle versus conventional ovarian stimulation. This is a retrospective single-center cohort study conducted at the GENERA IVF program, Rome, Italy, between September 2012 December 2018, including only patients, according to Bologna criteria, of advanced age, treatment through Natural Cycle or Between 585 patients were included within study. Two hundred thirty 355 In group, both per (6.25 vs 12.89%, respectively, p = 0.0001) patient101 with least one embryo-transfer (18.85 28.11% 0.025) resulted significant reduced. Pregnancy patient managed stimulation not significantly different compared (19.72 15.65% 0.228), but embryo was higher rather than subjected (13 8.28% 0.0468). No difference could be detected among two groups terms abortion ( 0.2915) live birth 0.2281). seems valid years low reserve, as an alternative