Multi-omics Quality Assessment in Personalized Medicine Through European Infrastructure for Translational Medicine (EATRIS): An Overview

• DOI: 10.1007/s43657-024-00170-0
• Publication Date: 2025-04-03T20:10:05Z
• Authors: Patricia Alonso-A...; Davide Baldazzi; Qiaochu Chen; Elisa Conde Moreno; Lorena Crespo-Toro; Kati Donner; Petr Džubák; Sara Ekberg; Maria Laura Garcí...; Daniela Gasparotto; Bishwa Ghimire; Jolein Gloerich; Alain van Gool; Janine Habier; Marián Hajdúch; Rashi Halder; Sari Hannula; Peter-Bram ´t Hoen; Hanna Lindgren; Yaqing Liu; Roberta Maestro; Tom Martin; Pirkko Mattila; Lukáš Najdekr; Kenneth Nazir; Anna Niehues; Anni I. Nieminen; Jessica Nordlund; Emanuela Oldoni; Elin Övernäs; Aino Palva; Maija Puhka; Ileana Quintero; Miren Edurne Ramo...; Esperanza Macaren...; Sabrina Saracino; Andreas Scherer; Leming Shi; Jarmila Stanková; Tanushree Tunstall; Beatrice Valenti; Janneke Weiss; Bhagwan Yadav; Yuanting Zheng; Patricia Žižkovičová
• Keywords: Personalized Medicine; Translational Medicine; Omics; Systems medicine

Abstract Molecular characterization of a biological sample, e.g., with omics approaches, is fundamental for the development and implementation of personalized and precision medicine approaches. In this context, quality assessment is one of the most critical aspects. Accurate performance and interpretation of omics techniques is based on consensus, harmonization, and standardization of protocols, procedures, data analysis and reference values and materials. EATRIS, the European Infrastructure for Translational Medicine (www.EATRIS.eu), brings together resources and services to support researchers in developing their biomedical discoveries into novel translational tools and interventions for better health outcomes. Here we describe the efforts within the Horizon 2020 EATRIS-Plus project and activities of member facilities of EATRIS towards quality assessment of pre-clinical sample processing, clinical omics data generation, multi-omics data integration, and dissemination of the resources in a Multi-Omics Toolbox, which is the principal deliverable of the EATRIS-Plus project for the consolidation of EATRIS towards translational medicine.