Distinguishing features of depression in dementia from primary psychiatric disease

• DOI: 10.1007/s44192-023-00057-y
• Publication Date: 2024-01-04T12:02:53Z
• Authors: Daniel W. Fisher; Jeffrey T. Dunn; Hongxin Dong
• Keywords: Depression; Vascular dementia

Abstract Depression is a common and devastating neuropsychiatric symptom in the elderly patients with dementia. In particular, nearly 80% of Alzheimer’s Disease dementia experience depression during disease development progression. However, it unknown whether shares same molecular mechanisms as presenting primary psychiatric or occurs persists through alternative mechanisms. this review, we discuss how clinical presentation treatment differ between disease, focus on major depressive disorder. Then, hypothesize several that may be unique to such neuropathological changes, inflammation, vascular events. Finally, existing issues future directions for investigation