Evaluation of Changes in Social Isolation and Loneliness with Incident Cardiovascular Events and Mortality

• DOI: 10.1007/s44197-024-00243-3
• Publication Date: 2024-05-27T09:01:33Z
• Authors: Yilin Chen; Huachen Xue; Yu Nie; Yujing Zhou; Sizhi Ai; Yaping Liu; Jihui Zhang; Yannis Yan Liang
• Keywords: Interquartile range; Social Isolation

Abstract Background It remains unknown how the patterns of change social isolation and loneliness are associated with onset cardiovascular disease (CVD) mortality. We aimed to investigate longitudinal association changes in incident CVD, all-cause mortality, CVD mortality subsequent cardiac function. Methods This prospective cohort study included 18,258 participants aged 38–73 years who participated visit 0 (2006–2010) 1 (2012–2013) using UK Biobank (mean age 57.1, standard deviation [SD] 7.4; 48.7% males). Social or was categorized into four patterns: never, transient, incident, persistent. Incident were ascertained through linkage data. Cardiac function assessed by magnetic resonance imaging a subsample ( N = 5188; 2, since 2014). Results Over median follow-up 8.3 (interquartile range [IQR] 8.1–8.6) years, compared never isolation, persistent higher risk (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.03–1.33), (1.42, 1.12–1.81) (1.53, 1.05–2.23) Likewise, strongly greater (1.13, 1.00–1.27), (1.28, 1.02–1.61) (1.52, 1.06–2.18). Conclusions Persistent posed substantially for dysfunction than other patterns. loneliness, along an increasing cumulative score, lower Graphical