One-click investigation of shape influence of silver nanostructures on SERS performance for sensitive detection of COVID-19

• DOI: 10.1016/j.aca.2022.340523
• Publication Date: 2022-10-18T00:37:45Z
• Authors: Zehua Li; Yong Luo; Yongchao Song; Qinglin Zhu; Tailin Xu; Xueji Zhang
• Keywords: Silver; SARS-CoV-2; COVID-19; Reproducibility of Results; Metal Nanoparticles; Spectrum Analysis, Raman; 01 natural sciences; Article; Nanostructures; 0104 chemical sciences; 3. Good health; Humans; RNA, Viral

Sensitive and accurate detection of SARS-CoV-2 methods is meaningful for preventing and controlling the novel coronavirus. The detection techniques supporting portable, onsite, in-time, and online data transfer are urgently needed. Here, we one-click investigated the shape influence of silver nanostructures on SERS performance and their applications in the sensitive detection of SARS-CoV-2. Such investigation is achieved by adjusting multiple parameters (concentration, potential, and time) on the integrated electrochemical array, thus various morphologies (e.g., bulk, dendritic, globular, and spiky) can be one-click synthesized. The SERS performance results indicated that dendritic nanostructures are superior to the other three with an order of magnitude signal enhancement. Such on-electrode dendritic silver substrate also represents high sensitivity (LOD = 7.42 × 10-14 M) and high reproducibility (RSD = 3.67%) toward the SARS-CoV-2 RNA sequence detection. Such approach provides great potentials for rapid diagnosis and prevention of diverse infectious diseases.