Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite

• DOI: 10.1016/j.actbio.2022.02.004
• Publication Date: 2022-02-09T02:03:27Z
• Authors: You Wu; Shoucheng Chen; Pu Luo; Shudan Deng; Zhengjie Shan; Jinghan Fang; Xingchen Liu; Jiaxin Xie; Runheng Liu; Shiyu Wu; Xiayi Wu; Zetao Chen; Kelvin W.K. Yeung; Quan Liu; Zhuofan Chen
• Keywords: Biocompatibility; Glutaraldehyde

Biogenic collagen membranes have been widely used as soft tissue barriers in guided bone regeneration (GBR) and (GTR). Nevertheless, their clinical performance remains unsatisfactory because of low mechanical strength fast degradation rate vivo. Although cross-linking with chemical agents is effective reliable for prolonging the time membranes, some adverse effects including potential cytotoxicity undesirable integration observed during this process. As a fundamental nutritional trace element, zinc plays an active role promoting growth cells regulating matrix. Herein, biogenic membrane was cross-linked glutaraldehyde-alendronate to prolong its time. The physiochemical biological properties were enhanced by incorporation zinc-doped nanohydroxyapatite (nZnHA), native structure preserved. Specifically, combined 1% 2% nZnHA seemed endow most appropriate biocompatibility capability among well offering period six weeks rat subcutaneous model. Thus, improving together promising strategy improvement membranes. significance research includes: We fabricated properties, prolonged uncompromised GA-alendronate doping. Tuning concentration ions can effectively manipulate process fabricated. proposed improve nZnHA.