Biomimetic camouflaged nanoparticles with selective cellular internalization and migration competences

• DOI: 10.1016/j.actbio.2022.11.059
• Publication Date: 2022-12-05T17:11:23Z
• Authors: Carla Jiménez-Jim...; Almudena Moreno-B...; Bianca Dumontel; Miguel Manzano; María Vallet-Regí
• Keywords: Biocompatibility; Nanocarriers

In the last few years, nanotechnology has revolutionized potential treatment of different diseases. However, use nanoparticles for drug delivery might be limited by their immune clearance, poor biocompatibility and systemic immunotoxicity. Hypotheses overcoming rejection from body increasing include coating with cell membranes. Additionally, source cell-specific targeting been reported when tumor cells Here we show that mesoporous silica membranes derived preosteoblastic could employed to develop treatments certain bone These were selected because well-established features. On other hand MC3T3-E1 migration capabilities towards defects. The process was here optimized ensuring loading More importantly, our results demonstrated how camouflaged nanocarriers presented cellular selectivity capability cells, which constitute inspiration future disease treatments. STATEMENT OF SIGNIFICANCE: This work presents a new nanoparticle formulation able selectively target cells. approach is based on Mesoporous Silica Nanoparticles coated overcome increase prolonging circulation time. We have Those shown appropriate releasing abilities confirmed. important novelty this