Association of Peripheral Blood and Cutaneous Eosinophils With Bullous Pemphigoid Disease Severity and Treatment Outcomes

• DOI: 10.1016/j.ad.2022.05.021
• Publication Date: 2022-06-02T05:49:51Z
• Authors: P.M. Garrido; M. Aguado-Lobo; P. Espinosa-Lara; L. Soares-Almeida; P. Filipe
• Keywords: Bullous pemphigoid; Severity of Illness Index; 3. Good health; Eosinophils; 03 medical and health sciences; Bullous dermatosis; Treatment Outcome; 0302 clinical medicine; Recurrence; Eosinophilia; Pemphigoid, Bullous; Humans; Biomarkers; Retrospective Studies

A dermal inflammatory infiltrate rich in eosinophils is a prominent histological feature of bullous pemphigoid (BP) and peripheral blood eosinophilia has been documented 50-60% BP patients. Nevertheless, the impact circulating eosinophil levels on remains poorly understood. The main objective this work was to investigate association with clinical immunological characteristics disease.Retrospective cohort study including all patients diagnosed between 2011 2020.The included 233 BP. mean baseline count 956.3±408.6×106/L number tissue at hot spot area 30.5±19.0. Patients disseminated presentation (i.e. BSA>50%) had significantly higher counts (P=0.028). Mucosal involvement associated lower (P=0.001). Requiring inpatient care relapsing were high (P=0.025; P=0.020, respectively). Among 68 who experienced relapse, 31 >500×106/L) relapse (44.2%). Peripheral correlated (r=0.82, P<0.001).Peripheral cutaneous may be useful biomarkers for disease activity treatment outcomes Monitoring allow early detection relapse.