Single-Isocenter Multitarget Stereotactic Radiosurgery Is Safe and Effective in the Treatment of Multiple Brain Metastases

• DOI: 10.1016/j.adro.2019.08.013
• Publication Date: 2019-09-16T23:11:50Z
• Authors: Joshua D. Palmer; Nikhil T. Sebastian; Jacquline Chu; Dominic DiCostanzo; Erica H. Bell; John Grecula; Andrea Arnett; Dukagjin M. Blakaj; John McGregor; James B. Elder; Lanchun Lu; Wesley Zoller; Mark Addington; Russell Lonser; Arnab Chakravarti; Paul D. Brown; Raju Raval
• Keywords: Isocenter

Multiple studies have reported favorable outcomes for stereotactic radiosurgery (SRS) in the treatment of limited brain metastases. An obstacle SRS management numerous metastases is longer time using traditional radiosurgery. Single-isocenter multitarget (SIMT) a novel technique that permits rapid therapy delivery to multiple There lack clinical evidence regarding its efficacy and safety. We report patients treated with this technique.We reviewed records intact or resected 1 5 fractions SIMT at our institution, least available follow-up magnetic resonance imaging. Survival, disease control, toxicity were evaluated Cox regression, logistic Kaplan-Meier analysis.We identified 173 1014 Median follow up was 12.7 months. beam-on 4.1 minutes. The median dose 219.4 cGy. overall survival freedom from intracranial progression 13.2 6.3 months, respectively. Overall did not differ between greater than less 4 lesions (hazard ratio, 1.03; 95% confidence interval 0.66-1.61; P = .91). Actuarial 1- 2-year local control 99.0% 95.1%, Rates grade 2 3 higher radionecrosis 1.4% 0.9%, respectively.SIMT delivered offers excellent acceptable postoperative This should be prospectively.