Radiation Therapy in the German Hodgkin Study Group HD 16 and HD 17 Trials: Quality Assurance and Dosimetric Analysis for Hodgkin Lymphoma in the Modern Era

• DOI: 10.1016/j.adro.2022.101169
• Publication Date: 2022-12-29T20:20:42Z
• Authors: Michael Oertel; Dominik Hering; Nina Nacke; Christopher Kittel; Kai Kröger; Jan Kriz; Michael Fuchs; Christian Baues; Dirk Vordermark; Rita Engenhart-Ca...; Klaus Herfarth; Peter Lukas; Heinz Schmidberger; Simone Marnitz; Peter Borchmann; Andreas Engert; Uwe Haverkamp; Hans Theodor Eich
• Keywords: Radioiodine therapy; Hodgkin's lymphoma

Radiation therapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. This analysis reports on RT quality in the recent HD16 and 17 trials German Study Group (GHSG).All plans involved-node radiation (INRT) HD were requested analysis, along with 100 50 involved-field (IFRT) 16 17, respectively. A structured assessment regarding field design protocol adherence was performed by reference oncology panel GHSG.Overall, (HD 16) 176 17) patients eligible analysis. In 16, 84% series evaluated as correct, significant improvement compared predecessor studies (P < .001). 76.1% INRT cases revealed a correct 69.0% IFRT-cases, which superior to previous Comparing IFRT, we found no differences percentage any deviation = .418) or major deviations .466). Regarding dosimetry, accompanied thyroid doses. different techniques, that intensity-modulated showed reduction high doses lung at expense increased low-dose exposure 17.The latest study generation GHSG demonstrates improved RT. modern could be established without deterioration quality. On conceptual level, individual consideration appropriate technique has performed.