The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy

• DOI: 10.1016/j.adro.2023.101273
• Publication Date: 2023-05-21T13:50:28Z
• Authors: Amy Berrington de...; Todd M. Gibson; Choonsik Lee; Paul S. Albert; Keith T. Griffin; Cari Meinhold Kit...; Danping Liu; Matthew M. Mille; Jungwook Shin; Benjamin V.M. Bajaj; Tristin E. Flood; Sara L. Gallotto; Harald Paganetti; Safia K. Ahmed; Bree R. Eaton; Daniel J. Indelicato; Sarah A. Milgrom; Joshua D. Palmer; Sujith Baliga; Matthew M. Poppe; Derek S. Tsang; Kenneth Wong; Torunn I. Yock
• Keywords: Record Linkage; Pediatric cancer

The physical properties of protons lower doses to surrounding normal tissues compared with photons, potentially reducing acute and long-term adverse effects, including subsequent cancers. magnitude benefit is uncertain, however, currently based largely on modeling studies. Despite the paucity directly comparative data, number proton centers patients are expanding exponentially. Direct studies potential risks benefits needed in children, who have highest risk radiation-related Pediatric Proton Photon Therapy Comparison Cohort aims meet this need.We developing a record-linkage cohort 10,000 photon therapy treated from 2007 2022 United States Canada for pediatric central nervous system tumors, sarcomas, Hodgkin lymphoma, or neuroblastoma, tumors most frequently protons. Exposure assessment will be state-of-the-art dosimetry facilitated by collection electronic radiation records all eligible patients. Subsequent cancers mortality ascertained linkage state provincial cancer registries Canada, respectively. primary analysis examine after therapy, adjusting confounders accounting competing risks.For aim comparing overall rates between we estimated that each treatment group there would 80% power detect relative 0.8 assuming cumulative incidence 2.5% 15 years diagnosis. To date, 9 institutions joined initiated data collection; additional added coming year(s).Our findings affect clinical practice providing first large-scale systematic comparison therapy.