Knowledge-Based RapidPlan Volumetric Modulated Arc Therapy Model in Nasopharyngeal Carcinoma

• DOI: 10.1016/j.adro.2025.101716
• Publication Date: 2025-01-13T16:53:52Z
• Authors: Szu-Huai Lu; Chun-Wei Wang; Hsiang-Kuang Liang; Chih-Kai Chang; Hao-Ting Lan; Shih-Fan Lai; Bing-Shen Huang; Wan- Yu Chen

RapidPlanTM (RP) Eclipse@, a commercial knowledge-based planning software, predicts radiation doses, enhancing treatment efficiency and quality. This study developed nasopharyngeal carcinoma (NPC) volumetric modulated arc therapy RP model assessed its quality against manual plans. The existing plans for 160 patients with NPC constituted the training cohort. An additional 33 formed testing cohort to compare based on dose-volume histograms, isodose curves, physician plan scores, selection. could be completed within 1 hour. demonstrated superior conformity compared in target volume 70. outperformed reducing organs-at-risks (OARs) doses. For advanced T3/4 tumors, chiasma optic nerve doses remained similar had higher physician-rated scores histograms of targets, OARs, holistic scores. Clinical acceptance rates reached 100%. Physicians chose over 31, 30, 28 doctors A, B, C, mainly because OAR sparing conformity. efficiently generates high-quality Further applications Eclipse single-institutional clinical flows multi-institutional collaborations or trials are warranted.